Episode's summary
As anti-science leaves research reeling, does evidence-based policy in a scientific society have much of a future? Michael Mann, Naomi Oreskes, Angie Rasmussen and Deb Houry discuss some of the sources and motivations that perhaps belie the current state of scientific affairs. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: The End street sign. Credit: Sanfel via Getty Images).
As anti-science leaves research reeling, does evidence-based policy in a scientific society have much of a future? Michael Mann, Naomi Oreskes, Angie Rasmussen and Deb Houry discuss some of the sources and motivations that perhaps belie the current state of scientific affairs. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: The End street sign. Credit: Sanfel via Getty Images).
Episodes
How science got here, and where next
ListenedAs anti-science leaves research reeling, does evidence-based policy in a scientific society have much of a future? Michael Mann, Naomi Oreskes, Angie Rasmussen and Deb Houry discuss some of the sources and motivations that perhaps belie the current state of scientific affairs. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: The End street sign. Credit: Sanfel via Getty Images).
Coral extinctions and chalky unknowns
ListenedAs two species of coral are killed off by the 2023 heatwave in the Florida reefs, the abilities of different plankton species to cope with rising CO2 remain crucially unknown. Also, retrospective research shows a strong suggestion that mRNA covid vaccination might serendipitously boost certain types of cancer immunotherapy. And, if you can’t identify changing agricultural crop types from satellite observations, why not just strap a camera to your bike helmet? Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jana Bennett-Holesworth (Photo: Dead elkhorn coral (Acropora palmata). Credit: Rolf von Riedmatten/Getty Images)
Paris agreement impacts and drought realities
ListenedTen years on from the Paris climate agreement, has it helped? Also, an international drought experiment, insights from 2D water, and social distancin in ants. Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jana Bennett-Holesworth (Photo: Small bushfire. Credit: Lea Scaddan/Getty Images)
Old faces and big spaces in small places
ListenedThe 2025 Nobel prizes are announced this week – how did Science in Action’s predictions fare? Science author and thinker Philip Ball judges. The Whitley Fund for Nature this week hosted a “People for Planet” summit, exploring possible solutions to save nature. Amongst the speakers was Prof Martin Wikelski, of ICARUS, who has spent many years tracking wildlife around the world using tiny radio sensors. As he describes to Roland, he shortly hopes to launch a network of satellites to enable a global system to help us learn how hundreds of species are faring. Also, a new “Human Disease Blood Atlas” gets a boost, as described by Mathias Uhlén of SciLifeLab. Could an annual blood sample become a standard primary healthcare routine, mapping key proteins and their concentrations to provide early warning of hundreds of diseases? Meanwhile Nozair Khawaja of Free University of Berlin has been revisiting data from the Cassini mission to Enceladus, one of Saturn’s moons, back in 2008. His new analysis increases the…
A mystery satellite has been jamming GPS in Europe
ListenedScientists detect for the first time an unknown source of GPS interference coming from space. Also, as AI begins to design more and more DNA sequences being manufactured synthetically, how can those manufacturers be sure that what their customers are asking for will not produce toxic proteins or lethal weapons? And… how camera traps in polish forests reveal that the big bad wolf is more scared of humans than anything else. For that last few years instances of deliberate jamming and interference of GNSS signals has become an expected feature of the wars the world is suffering. Yet this disruption of the signals that all of us use to navigate and tell the time nearly always emanate from devices on the ground, or maybe in the air. But in ongoing research reported recently by Todd Humphreys of University of Texas at Austin and colleagues around the world is beginning to reveal that since 2019 an intermittent yet powerful signal has been causing GPS failures across Europe and the North Atlantic. The episodes have…
Autism and the epigenetics of early brain development
ListenedEpigenetic changes during early brain development, and the complexities of autism. Also, how bacteria learn to parry antibiotics, the subterranean burp that shook the Island of Santorini, and new guidance for sharing land between farming space and living space for the pollinators on which it depends. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: Blastocyst embryo, light micrograph. Credit: Science Photo Library via Getty Images).
Stephen Hawking gets it right again
ListenedGravitational waves show two black holes merge just how Hawking predicted. Plus, a space mission without a target. And a Space probe without a confirmed budget. In January 2025 the LIGO gravitational wave observatories witnessed two distant black holes spinning into each other. In the ten years of LIGO’s operations, that’s not a first. But the instruments have been improved to such an extent that this time some very important predictions of General Relativity and out understanding of black holes could be tested. As Birmingham University’s Alberto Vecchio says, the elegant simplicity of the mathematics of black holes has passed a test, in particular Stephen Hawking’s prediction that the surface area of merging black holes can only be increased. Space craft have met comets before. But because spaceflight takes so long to plan and fund, we’ve only sent them to comets with human-lifetime orbital periods so far, because we know when they’re arriving. ESA wants to meet one we’ve never seen before, one that has…
Asteroids, comets and where to find them
ListenedScientists’ latest plans for welcoming interstellar visitor 3I/Atlas next month, and arranging a rendezvous with comet Apophis in 2029, as heard this week at the EPSC-DPS international planetary science joint meeting in Helsinki. Presenter: Roland Pease Producer: Ella Hubber, with Alex Mansfield Production coordinator: Jana Bennett-Holesworth Image: Artist's impression of an asteroid in space (Credit: European Space Agency/ESA Science Office)
Why is Afghanistan so vulnerable to earthquakes?
ListenedDespite the relatively low magnitude, earthquakes in Afghanistan this week have left more than1000 dead. Afghan researcher Zakeria Shnizai from the University of Oxford unpicks some of the main causes of the country’s vulnerability to earthquakes. Also this week, we talk to the climate scientist who led a 400+ page rebuttal to the US Department of Energy’s report on climate change. We hear about research which has mapped the activity of over 600,000 neurons in 279 regions of the mouse brain to learn more about how decisions are made. And we get the latest updates on 3I/ATLAS, the latest interstellar comet streaking its way across our solar system, just before it disappears behind the sun. Presenter: Roland Pease Producer: Ella Hubber Production Coordinator: Jana Bennett-Holesworth (Image: Magnitude 6.0 earthquake strikes eastern Afghanistan. Credit: Anadolu via Getty Images).
How Fear Spreads
ListenedWhat can modern epidemiological methods tell us about French Revolutionary history? Also, the origins of horse riding, solar systems, and star dust itself. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: Storming of the Bastille Paris France 1789 illustration. Credit: Grafissimo via Getty Images).
Not cold fusion all over again
ListenedA desktop nuclear fusion reactor that uses electrochemistry to up the ante. Also, a global survey of human wildfire exposures finds Africa burning ahead, plus tiny swarming robots and record-breaking 2024 ice melts from glaciers on Svalbard. Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jana Holesworth (Photo: The Thunderbird Reactor at the University of British Columbia (UBC). Credit: Berlinguette Group/UBC)
Vaccine study retraction request rejected
ListenedUS Health Secretary RFK Jr’s call to retract a study on childhood vaccines is resisted by the journal. Also antibiotics get designed by AI, and a new way for stars to die. A study focussing on Danish childhood vaccination data has attracted the US Secretary for Health’s anger, as RFK jr calls for the journal in which it was published, the Annals of Internal Medicine, to retract it. The Editor, Christine Laine, talk to Science in Action about the strengths and challenges of observational studies. The cuts to prestigious US federal science funded research continue, as last week it was announced that $500 million funding for future mRNA vaccines would be withdrawn. Barney Graham, one of the pioneers in the field and prominent during the Covid vaccines, argues that the research will still happen, though maybe not in the US, as mRNA has become a fundamental area of global research. Meanwhile, strides are being made in the field of synthetic biology as Jim Collins and colleagues at MIT and Harvard have used AI to…
An end to allergic reactions?
ListenedAs the United States secretary of health and human services, Robert F Kennedy Jr., announces a $500 million cut to mRNA vaccine research in the United States, we hear a statement from the Nobel Prize winning biologist who made mRNA vaccines possible. A team of scientists from Northwestern University have uncovered the pathway believed to protect some people from allergic reactions (even when they are sensitive to an allergen) and have tested a drug which could protect the most severely allergic. Also this week, satellite data shows that large parts of the Earth are running dangerously low on ground water. And although people often believe scientific fraud is committed by a few bad actors, a new paper uncovers networks of journals, editors, and authors who are allegedly cooperating to publish fraudulent papers. Presenter: Roland Pease Producer: Ella Hubber and Alex Mansfield Assistant producer: Minnie Harrop Production co-ordinator: Jana Bennett-Holesworth (Photo: Allergy testing. Credit: Peter Dazeley/Getty…
Getting ahead of tsunamis
ListenedAfter most of the population of the Pacific rim sought higher ground this week, we speak with the architect of the tsunami warning technology. Also how aging Killifish might help us probe our senior moments. This week, an M8.8 earthquake near Kamchatka in the western pacific led to tsunami evacuation alerts thousands of miles away. Seismologist Judith Hubbard was writing about the area in the days leading up to it, following a M7.4 event 9 days before, which we now know to categorize as a foreshock. As she says, it’s these subduction zones between tectonic plates that give out the most energy, produce the biggest quakes, leading to the worst tsunamis. The Tsunami alarms were based on modelling developed by Vasily Titov of NOAA’s Pacific Marine Environmental Laboratory in Seattle. Having studied these phenomena for many decades, he describes the fine balance between the potential accuracy of a prediction, and the practical actionable advice authorities need to give out to save as many lives as possible.…
Discovering Betelgeuse’s Betelbuddy
ListenedHave we found Betelgeuse’s ‘Betelbuddy?’ An astronomical mystery seems to be solved as the long-predicted stellar companion to the bright star Betelgeuse has been detected by a team of researchers led by Steve Howell of the NASA Ames Research Center using the Gemini North telescope in Hawaii. Steve discusses this breakthrough alongside astronomer Andrea Dupree of the Harvard Smithsonian Center for Astrophysics, who has discussed the predictions of this star on previous Science in Action programmes. Malaria is a mosquito-borne disease caused by the parasite plasmodium that kills more than half a million people each year. George Dimopoulos of the Johns Hopkins Malaria Research Institute is using gene editing and gene drive technology to target the parasites as they develop in the guts of mosquito. Can this new method disrupt the malaria parasite life cycle safely and sustainably? Our gut microbiomes are linked to our brains, but how can the bacteria in our colon communicate with our nervous system? M. Maya…
Biggest black hole merger observed
ListenedTwo black holes have collided and combined in the largest merger yet observed. Mark Hannam of Cardiff University and member of the study explains how the Interferometer Gravitational Wave Observatories (LIGO) detected this ‘violent’ event through spacetime. The lifestyle of ancient humans had an impact on their risk for infectious diseases. Astrid Iversen of the University of Oxford explains how the shift away from being hunter-gatherers played a role in the origins of human pathogens. Nitrogen fixation, or the process of organic compounds accessing nitrogen from the atmosphere via microorganisms, plays a key role in climate modelling. But prior estimations have long been missing key data to make accurate analysis. Carla Reis Ely of Oak Ridge Institute for Science and Education shares the updated facts and figures on global nitrogen fixation. How intelligent is artificial intelligence? Can AI start discovering new scientific laws in the year? Keyon Vafa of Harvard University put several AI models to the test…
Tracking ocean circulation systems
ListenedThe European Space Agency plans to use satellite gravity data to track weakening ocean circulation systems. Rory Bingham of the University of Bristol explains how these satellites can ‘weigh’ the Earth’s water and might help resolve whether we’re approaching the climate tipping point of a shutdown of ocean circulation in the Atlantic Ocean, something we've been following for a while. Scientists have been able to retrieve ancient proteins from fossilized tooth enamel in the Canadian High Arctic. Ryan Sinclair Paterson from the University of Copenhagen tells us how he can fill in the blanks of the molecular tree of life with these proteins from over 20 million years ago. A few weeks ago, we discussed evidence of an impact of a massive crater in north-western Australia from over 3 billion years ago. However, recent independent evidence from another team of geologists indicate that the size and age of this crater’s impact may not be what some had previously thought. Alec Brenner of Yale University talks us…
Bird flu surges in Cambodia
ListenedThere's a surge in cases and deaths from H5N1 bird flu in Cambodia - we hear what's the driver and how concerned we should be. Erik Karlsson, Head of Virology at the Pasteur Institute in Phnom Penh and director of the WHO’s H5 Reference Laboratory has been watching the uptick. An interstellar interloper has been spotted entering our solar system. Most likely a comet, and possibly visible in the sky, it’s just the third such visitor we’ve ever seen. Josep Trigo of Spain’s Institute of Space Sciences (CSIC) and the Catalan Institute for Space Studies is one of many astronomers keeping his eye out. DNA from an ancient Egyptian buried in cave 2,500 BCE, the oldest to date, tell a tale of travelling ancestors, according to research led by Adeline Morez of Liverpool John Moore’s University and published in Nature. Also, Corey Allard of Harvard university has been looking at a particular type of sea slug. Published in the journal Cell, the work has been trying to work out how these slugs effectively nurture and…
Vera C. Rubin Observatory first images
ListenedA spectacular new 10-year telescopic survey of the universe gets underway in Chile. Also, a project to create human chromosomes completely synthetically. Almost three decades ago Tony Tyson (now of UC Davis) and colleagues were standing in the control room of the world’s biggest (at the time) digital astronomical camera. It was 3am when he suggested astronomers could do better. This week, the Vera C Rubin Observatory unveiled first images from the telescope he envisioned. Unprecedented in so many ways, expect many discoveries to come from this unique machine. Another ambitious project known as SynHG kicks off this week, on the 25th anniversary of the publication of the first draft of the human genome, with a plan to develop the technology to potentially create a whole synthetic version. Jason Chin of MRC Laboratory of Molecular Laboratory in Cambridge and colleagues will be extending their previous work in synthetic biology to human DNA, whilst Joy Zheng of the University of Kent will be running a parallel…
Half a universe once lost now found
ListenedThe universe is thought to consist of 70% Dark Energy, 25% Dark Matter, and just 5% Baryonic matter which is the atoms that make up you and me. At least, that’s what the models suggest. But a well-kept secret between astronomers and cosmologists for all these years has been that they have not actually ever seen almost half of that 5% normal matter because it is thinly dispersed as gas between the galaxies and galactic clusters. This week, two studies have been published putting that right. Satisfactory model-match #1: Liam Connor of Harvard University with colleagues from Caltech have been using a mysterious phenomenon called Fast Radio Bursts (FBRs) to infer what the intergalactic medium is in between, and how much of it there is. Satisfactory model-match #2: Konstanios Migkas of Leiden University and colleagues have been looking at the very faint x-ray signal from the intergalactic medium, removing the incidental x-ray sources such as black holes, and have managed to identify some structure - in this case…
The first solar polar pictures
ListenedESA’s Solar Orbiter camera probe begins raising its orbit towards the sun’s poles, whilst Betelgeuse’s elusive buddy continues to sneak past our best telescopes. Earlier this year, Solar Orbiter started to stretch its orbit over greater latitudes – effectively standing on cosmic tiptoes to catch a glimpse of the Sun’s poles. This week, we have seen the first ever pictures of them, and as solar scientist Steph Yardley tells us, the views will only get better. Meanwhile, Andrea Dupree of the Harvard Smithsonian Center for Astrophysics and colleagues have had time to study new Hubble and Chandra telescope observations of the iconic star Betelgeuse searching for signs of its hypothesised binary companion – dubbed “Betelbuddy”. The papers that appeared on the Arxiv pre-print server have not yet been fully peer-reviewed, but it seems astronomers will have to keep looking. Humans use machines to read gene sequences as best they can, but it takes time and is not perfect because we do not know what all of it means.…
Potential fungal 'Agroterror'?
ListenedWhat is Fusarium graminearum and why were scientists allegedly smuggling it into the US? Also, Alpine Glacier collapse and an HIV capitulation. The FBI has accused two Chinese scientists of trying to smuggle a dangerous crop fungus into the US, calling it a potential agro-terrorist threat. But the fungus has long been widespread across US farms, and elsewhere, and is treatable. So what’s going on? Frédéric Suffert, Senior researcher in plant disease epidemiology at France’s National Research Institute for Agriculture, Food and Environment, gives us some insight. Last week, a glacier above the swiss village of Blatten collapsed and up to 12 million tonnes of ice and rock buried the idyllic, yet thankfully all-but evacuated, hamlet below. Daniel Farinotti of the Swiss Federal Institute of Technology explains how it was monitored more than any such event before, and maybe, despite the tragedy, could help inform the science of such events in a warming world. Amongst the latest cuts to scientific funding by the…
Thirteen months to a chip off the moon
ListenedChina is aiming to join the small club of nations who have successfully returned scientific samples of asteroids for analysis on earth, teaching us more about how our and potentially other solar systems formed. Tianwen-2 launched successfully this week, bound for an asteroid known as Kamo‘oalewa, which sits in a very strange orbit of both the earth and the sun, making it a “quasi-satellite”. Last year, scientists including Patrick Michel of the Côte d'Azur Observatory in France, published an intriguing suggestion that Kamo‘oalewa might in fact not be a conventional asteroid, but instead be a small piece of our moon that was ejected when the Giordano Bruno crater formed. In a little over a year from now, we might find out if that is right. Do you have to hold text at arm’s length to read properly? Qiang Zhang, professor of physics at the University of Science and Technology of China, whose team recently published their demonstration of using a technique from radio astronomy but using optical light. Active…
WHO Pandemic Agreement reached
ListenedThis week, 124 countries agreed at the World Health Assembly in Geneva on measures aimed at preventing a future pandemic. The agreement very strongly favours a “One Health” approach, appreciating how so many potential pathogens originate in human-animal interactions. Still to agree on the terms of how to share pathogens and information with global science and vaccine researchers, eventually the treaty will need to be signed by at least 60 countries. But can the inequity between countries of the global south and north, and issues of intellectual property, be bridged? A new study on origins of the Nigerian mpox epidemic points strongly to zoonotic crossovers and mobility of wildlife in West Africa. Edyth Parker of Redeemer’s University in Nigeria describes their phylogenetic tree. Can the bovine form of H5N1 flu infect pigs, and could domestic pig populations then provide a crucible for further variants to develop? Jürgen Richt of Kansas State University and colleagues have been investigating. We need to keep…
Vaccinating rabies’ reservoir dogs
ListenedIn 2015, the World Health Organisation set the goal of eradicating rabies deaths from dog-bites to “Zero by 2030”. A team at the University of Glasgow and colleagues in Tanzania have been assessing the efficacy of dog vaccination schemes for reducing the numbers of human infections over the last 20 years. As Prof Katie Hampson tells Science in Action, in rural areas especially, vaccinating dog populations does work, but you need to keep at it, and not leave patches untouched. It should be funded as a public health measure, rather than a veterinary issue. Last weekend, the remains of a failed 1972 Soviet mission to Venus landed harmlessly somewhere back on earth. As the BBC’s Maddie Molloy explains, the fears were that the robust lander craft would survive re-entry into earth’s atmosphere as it was originally engineered to withstand the harsh pressures and chemistry of Venus. How and why then would sketches be emerging of Chinese plans to launch a sample-return mission to Venus in the next decade? Science…
Gain-of-Function: Loss-of-Funding
ListenedThis week, the White House posted an executive order which details the administration’s intent to stop ‘dangerous gain-of-function research’. We talk to Gigi Gronvall, an immunologist and biosecurity expert at Johns Hopkins University who fears the timing and added bureaucracy could stop all sorts of important biosciences unnecessarily, and that the order is somewhat ideologically driven. Also, Nasa’s Juno mission has provided data on the most powerful volcanic event ever recorded, which took place on the planet Io, one of Jupiter’s moons. Hellish Io, squeezed as it is by the immense gravity of Jupiter, has not been observed from its poles before in this manner. Last week at EGU25, Science in Action got to speak with the mission’s principal investigator, Scott Bolton of Southwest Research Institute. Still on Jupiter’s moons, we also ask whether there could there be life on Ganymede, Callisto, and Europa? Scientists believe their glaciated oceans may harbour conditions suitable for life. Also at the EGU…
Scientists of the world unite
ListenedScientists from around the world have gathered together at the annual European Geosciences Union general assembly, to discuss current projects, working hypotheses and potential findings. There are nearly 18,000 in attendance this year and there is much to learn. AMOC – the Atlantic Meridional Overturning Circulation - brings warmth to the north and cooler waters to the south in huge volumes. Climate modellers have expressed concern for its collapse (and subsequent weather chaos) as temperatures rise more generally, but others have said it is more resilient. But Stefan Rhamstorf has announced that extending the models past 2100 can show a different picture. The odds have shifted from 10% to more like 50/50 if the Paris climate target is missed. Has such climate change ever occurred before? And if so, what drove it? Hana Jurikova and colleagues have been using novel techniques to detect a link between atmospheric CO2 levels and rapid climate change in the geological past, and explains how boron records in…
Wet market SARS CoV-2 origins revisited
ListenedLast week, the website covid.gov looked very different, containing information on coping with covid and US research. This week it leads you to a White House webpage outlining the lab-leak hypothesis – that the pandemic was the result of dodgy lab work at the Wuhan Institute of Virology. The scientific consensus however continues to suggest a zoonotic crossover event. And a preprint recently published by Zach Hensel of ITQB NOVA (NOVA University Lisbon) and Florence Débarre of the Sorbonne, adds new early sequences to the evidence base. As they suggest, it doesn’t seal the debate, but it certainly doesn’t surprise the scientists. As the Trump administration continues to rattle swords with US science, we speak with Lisa Fazio of Vanderbuilt University who found out abruptly her funding from the National Science Foundation is ending, and Don Ingber, founding director of Harvard University’s Wyss Institute about the impacts they are feeling from the federal belt tightening. Finally we learn this week of an eerie…
Any more for Moore’s Law?
ListenedAfter 60 years of doubling computer complexity every two years, can Moore’s law still predict the future power of the devices we use? In 1965, electronics pioneer Gordon Moore was asked to predict the next ten years of progress with the then new-fangled silicon integrated circuits. He estimated, based on physics and manufacturing technologies then available what seemed remarkable: that every two years they would double in complexity, and halve in price, until 1975. 60 years on, perhaps the even more remarkable thing is that they just kept doubling. Can Moore’s law hold into future decades? What are the next technological innovations that might keep it running? Sri Samavedam is the vice president for silicon technologies at imec in Belgium, whose job it is to think about the practicalities of manufacturing the next generations of chips years before they become real. Scott Aaronsen of the University of Texas is a thinker in the field of Quantum Computing – could quantum computing keep the rate of growth going?…
Researching pain, painlessly
ListenedPain, particularly chronic pain, is hard to research. New therapeutics are hard to screen for. Patients are not all the same. Sergui Pascu and colleagues at Stanford university have been growing brain samples from stem cells. Then they began connecting different samples, specialised to represent different brain regions. This week they announce their most complex “assembloid” yet, one that even reacts to hot chilli, passing a signal from the sensory neurons through to the thinking bits. The hope is that it can provide insights on how pain, and potential painkillers, work. Human brains are notoriously large, particularly infants. Whilst for primates the human pelvis is quite narrow, to allow us to walk and run on two legs. This notoriously makes childbirth, well, not as straightforward as most other species. This evolutionary “obstetric dilemma” has been debated for decades. Marianne Brasil, of Western Washington University, and colleagues, have published this week a huge study of contemporary human genes and…
Earthquakes and the first breath of life on Earth
ListenedHow Myanmar’s tragic earthquake left a 500km scar on the surface of the earth in just 90 seconds. Also, more hints of a link between shingles vaccines and reduced dementia, and how earth’s first oxygen breathers seem to have evolved way before there was enough oxygen to breath. Judith Hubbard is a seismologist and earthquake analyst who has been gleaning what scientific information we can find on the tragic quake that struck Myanmar last week. There seems to be some sort of link between the herpes virus that causes shingles and some people’s risk of Alzheimer’s dementia. At least, the latest paper appears to confirm so, according to an analysis published in Nature this week. Pascal Geldsetzer of Stanford University and colleagues have looked at data from public health records in NHS Wales in the UK, and have retrospectively performed a “natural experiment”, finding a clear suggestion that a vaccine against the virus that causes shingles seems to confer a lower likelihood of developing dementia over the…
Breakthrough antivirals and fresh US grant cancellations
ListenedThis week, after five years of research, two newly discovered antiviral molecules have been shown to combat coronaviruses. Johan Neyts of the Rega Institute for Medical Research in Leuven outlines how he hopes the new molecule developed by his team might help us deal with emerging pandemics in the future. But as the US halts all Covid related research, will drugs like these ever hit the shelves? Among the grants terminated this week by the National Institute for Health is a programme called AViDD, AntiViral Drug Discovery, supporting 9 independent consortia. Annette von Delft of Oxford University and Ed Griffen of the drugs discovery company MedChemica spoke to us about the overnight shut down of years of work and importance of antiviral development. The longest ever carbon-based molecules have been discovered by the Mars Curiosity rover. Caroline Freissinet of the Laboratoire Atmosphères et Observations Spatiales talked us through the meticulous planning and geological chance that made this possible, and…
Columbia cuts and "transgender mice"
ListenedThere is continued upheaval in US scientific institutions under the new Trump administration. This week $400 million dollars-worth of grants have been frozen at Columbia University in response to “illegal” protests on the campus. President Trump also recently accused the Biden Administration of spending $8 million dollars on "transgender mice" experiments. We talk to two scientists, Kelton Minor and Patricia Silveyra, who have been affected in different ways. Also, as the first data from the European Space Agency's Euclid mission is released, Euclid project leader Valeria Pettorino tells us how this impressive space telescope hopes to unlock the secrets of the dark universe. And, around this time last year we heard about the H5N1 strain of bird flu finally jumping to the Antarctica Peninsula. Today, an expedition led by virologist Antonio Alcami confirms that the virus has spread to every animal species at each site they visited. Presenter: Roland Pease Producer: Ella Hubber Production co-ordinator: Jana…
New warnings, familiar faces, and radio pulses
ListenedFive years after the WHO pandemic announcement, an H5N1 call to arms from global health leaders. Also, the oldest western European face is found, the oldest impact crater possibly identified, and strange radio signals from space maybe explained. Presenter: Roland Pease Producer: Alex Mansfield Production Coordinator: Jana Bennett-Holesworth (Image: US To Boost Egg Imports As Prices Soar On Bird Flu. Credit: Bloomberg via Getty).
An uncertain forecast for meteorology
ListenedAs the new administration in the US continues to make cuts to government agencies and scientific funding, NOAA – the National Oceanic and Atmospheric Administration has been particularly trimmed. This week the professional organisation for weather forecasters – the American Meteorological Society has published a statement pleading for clemency, arguing that the whole US Weather Enterprise is at risk. It’s current president elect, veteran weather broadcaster Alan Sealls describes how it’s not just US weather forecasts that appear bleak. As the journal Science Advances publishes a special edition highlighting areas of women’s health research, we speak with two researchers who may have found a link between menopause – or perhaps hormonal changes – and the age it occurs, with Altzeimer’s Disease. Madeline Wood or the University of Toronto and Kaitlin Casaletto of UCSF describe how synaptic health – the fitness of the brain - at death seems even to be less attenuated in women who used hormonal therapy during…
Asteroid 2024 YR4 crisis averted?
ListenedJust two weeks ago the world learned of an asteroid that had an almost 3% chance of striking earth in less than a decade. Astronomers kept looking, and a team including Olivier Hainaut at ESO’s Very Large Telescope at Palanar, in Chile, have managed to narrow down the uncertainty such that we now know it will definitely not hit the earth. The secret of making such observations after most telescopes could no longer see it was down to the exceptionally dark skies there. But these may be under threat. A plan has been made to build a large power plant, including sustainable hydrogen production around 11km away from the otherwise isolated site, and astronomers around the world are rallying to call for the plant to be built further away so that its construction will not spoil the otherwise unique observation conditions. One of the signatories of a petition to that effect is Julia Siedel, also of ESO, who just last week published the first 3D atmospheric analysis of an exoplanet’s climate. As she explains, future…
Who runs science?
ListenedThe Lancet this week features a paper calling for a financially sustainable network of influenza labs and experts across Europe. Marion Koopmans was one of the 32 expert signatures, and she describes how Europe needs to learn some lessons from the model developed previously in the US. The ongoing worries around avian H5N1 would be a great example of why funding for that sort of frontline strategic science needs not to be reliant on ad-hoc, potentially political, funding grants. This weekend, a conference is taking place in Asilomar, CA, to mark 50 years since the 1975 conference there at which scientists developed some rules and guidelines around the future practice of genetic science. The historic Asilomar conference is celebrated by many as the moment scientists first demonstrated that they could spot risks, and self-regulate their activities, around novel and disruptive technologies. Author and scientist Matthew Cobb of the University of Manchester, and Shobita Parthasarathy of the University of Michigan…
Hits from space
ListenedThis week the recently spotted asteroid 2024 YR4 had its odds of missing us “spectacularly” slashed by 1 percentage point. Still nothing to worry about maintains Patrick Michel of the International Asteroid Warning Network, and he expects that with better tracking data in the next few months (even courtesy of the JWST) that tiny chance of collision will fall further. However, as he explains, it’s very comforting to know that we now have such a sophisticated tracking network, and even better, thanks to NASA’s DART mission, even a demonstrable method for doing something about it if the numbers go the other way… But other extraterrestrial bombardments are harder to detect at all. This week scientists of the KM3NeT collaboration report in the journal Nature their detection of the most energetic neutrino ever noticed. Almost countless numbers travel through the earth – and us – every second, but this little beauty arrived from deep space, plummeting through hundreds of miles of rock and sea (via Malta) to collide…
Earthquakes swarms and whale chart toppers
ListenedThe mystery swarm of small earthquakes near the island of Santorini beg for more data collection. Also, the National Oceanic and Atmospheric Administration (NOAA) in the US goes offline and whales learn song like kids learn language. Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Josie Hardy (Photo: Greece earthquake. Credit: AFP)
Make science great again
ListenedNasa's OSIRIS-REx mission to collect a sample from an asteroid has been a great success. Asteroid Bennu's sample yields a watery pool of history, thanks to an international team of scientists including the London Natural History Museum's Sarah Russell. Also, in a week of tumultuous changes to federal funding and programmes, we hear from some US scientists affected and concerned by Executive Orders from the White House. Betsy Southwood, formerly of the Environmental Protection Agency, is worried not just about the government employees’ careers, but the environment itself and the whole of environmental science in the US and the world. Chrystal Starbird runs a lab at the University of North Carolina and is worried about the fate of grants aimed at diversifying scientific expertise, but also that some grant schemes are getting erroneously included in the anti-DEI clampdown. And Lawrence Gostin is an eminent health lawyer, proud of the NIH and all it has achieved. Presenter: Roland Pease Producer: Alex Mansfield…
Arctic carbon starting to flip
ListenedThirty per cent of the Arctic is switching from carbon sink to carbon source. But could future fertilizer be made deep underground using less resources? Also, how and perhaps why globally 2024 had the highest number of fatal landslides in over 20 years, and an unexpected sound from space prompts a re-evaluation of how the earth’s magnetic field interacts with the environment around it. Presenter: Roland Pease Producer: Alex Mansfield Production co-ordinator: Jana Bennett-Holesworth (Photo: Magnificent icebergs. Credit: MB Photography/Getty Images)
AI antivenoms and vegetarian hominids
ListenedNew types of snake-bite anti-venoms are designed by AI. Also, how much meat did human ancestors eat? How the Baltic Nord Stream gas pipeline rupture of 2022 was the biggest single release of methane ever caused by humans, and that Pluto met Charon, not with a bang, but more of a kiss. Using a high precision technique for spotting different isotopes of Nitrogen, Tina Lüdecke of the Max Planck Institute for Chemistry has concluded that a group of early hominin Australopithecus living in South Africa were predominantly vegetarian, putting the date that human ancestors started eating meat (and thence growing bigger brains) to more recently. The technique, she thinks, can enlighten prehistoric food webs and ecologies from millions of years ago. Last year’s Nobel prizes showed the potential new techniques of AI to design synthetic proteins. Timothy P Jenkins and colleagues decided to try designing treatments for snakebite venoms, with remarkable apparent success. It could save many thousands of lives a year. Since…
First US avian flu fatality
ListenedH5N1 bird flu is still spreading across farms in the USA and this week claimed its first human life in North America - an elderly patient in Louisiana infected by backyard poultry. But last week, Sonja Olsen, Associate Director for Preparedness and Response in the CDC’s flu division, and her colleague Shikha Garg, published new analysis in the New England Journal of Medicine summarizing the human cases and epidemiology so far. A lab study underscoring a suspected link between the virus responsible for cold sores, and Alzheimers, the most common form of dementia, has been published in Science Signalling this week. The study, by Dana Cairns of Tufts University, looks at whether repetitive brain trauma – another risk factor - adds to the evidence that latent herpes simplex can be involved. Song Lin, a chemist at Cornell University who has won prizes for pioneering the use of electrical currents to drive chemical reactions rather than heat, has teamed up with Cornell micro engineer Paul McEuen to power up a new…
Five years of Covid: Part two
ListenedSars CoV-2 has been with us for five years. In the second of a 2-part special, Science in Action asks how well was science prepared for it? And are we any better prepared for the next one? Presenter: Roland Pease Producer: Alex Mansfield, with Debbie Kilbride Production Coordinator: Jana Bennett-Holesworth
Five years of Covid: Part one
ListenedSars CoV-2 has been with us for five years. In the first of a two-part special, Science in Action asks how well was science prepared for it? And are we any better prepared for the next one? Presenter: Roland Pease Producer: Alex Mansfield, with Debbie Kilbride Production co-ordinator: Jana Bennett-Holesworth
Sun Grazing
ListenedNew insights into how our skin learns to tolerate and co-exist with bacteria on its surface show great potential for the development of simpler and less invasive vaccines. Stanford University’s Djenet Bousbaine has published two papers in Nature detailing the microbiological research and mouse vaccination experiments that could change the future of immunisation. The Sun is the hardest place in the Solar System to reach. But by the time the next edition of Science in Action is on air, NASA’s Parker Solar Probe will have swooped through the scorching corona layer of the Sun, re-emerged, and be readying itself to relay the details of magnetic fields and particle storms to the team. NASA Helioscience deputy manager, Nicky Rayl, reveals all about the mission and explains why the Parker Probe’s future looks bright. And a trip half a billion years back - and then some - to the dawn of complex life here on Earth. Microfossil hunter Shuhai Xiao, from Virginia Polytechnic Institute and State University, has been…
Warming oceans kill millions of birds
ListenedHeatwaves in the pacific ocean have had a devastating effect on seabird populations in the north eastern US. Julia Parrish and colleagues publish this week 4 million deaths of Alaskan common murres attributable to rising water temperatures during 2014-16, representing half the population. One idea is that the fish on which the birds feed swim at deeper depths to find cooler temperatures, taking them below the depth the birds can dive. Worse, the reduced population numbers have endured almost ten years later. Pre-eclampsia affects up to 5 percent of pregnancies across the world. It reduces blood flow through the placenta, endangering mother, and even hindering the development of the foetus. But a promising approach to a possible therapy is described by Kelsey Swingle and colleagues this week. Much like some covid vaccines, by using a sort of lipid nanoparticles to deliver mRNA directly to the placenta in pregnant mice has resulted in healthier outcomes by widening the placental capillaries, allowing blood to…
Bovine H5N1 gets a sniff of humans
ListenedScientists have found that just one mutation in the current H5N1 virus in cattle can switch its preference from avian to human receptors. Jim Paulson and colleagues at the Scripps Institute did not use the whole virus to investigate this, but proteins from one of the Texas farm workers found to be infected. It suggests the bovine H5N1 virus has already evolved subtly. Meanwhile, Richard Webby of St. Jude Children's Research Hospital in Memphis helps us catch up on the latest known about the case of the Canadian teenager taken seriously ill a month ago with a different variant of avian H5N1. A debate has been rumbling this last year about the extent of ocean warming by, perhaps paradoxically, the reduction of particulate pollution from the fuel used by ships. The idea is that the small particles of sulphates and nitrates in the soot from funnels actually formed clouds over shipping lanes out at sea. This in turn sheltered the oceans to some extent from solar radiation, thus making latter decades of the 20th…
Fifty years of Charm
ListenedNovember 1974 became known as the “November Revolution” in particle physics. Two teams on either side of the US discovered the same particle - the “J/psi” meson. On the "J" team, at the Brookhaven National Laboratory, Sau Lan Wu and colleagues were smashing protons and neutrons together and looking for electrons and positron pairs in the debris. Over at Stanford on the other side of the US, Dr Michael Riordan was in a lab with the "psi" team who, in some ways the other direction, were smashing electrons and positrons together to see what was created. They both, unbeknownst to each other, found a peak around 3.1Gev. It was shortly after that the full significance was clear. The existence of this particle confirmed a new type of quark, theorised in what we now call the Standard Model, but never before observed - the Charm quark. And with Prof Sau Lan Wu’s team’s subsequent discovery of gluons – the things that hold it all together – a pattern appeared in what had been the chaos of high energy physics and the…
Faster, wetter, worse tropical storms
ListenedIt is hard not to have noticed the intensity of storms around the world this year, not least the Atlantic storms that battered the eastern US. A new study, using a new technique, confirms their attribution to climate change, and goes further, finding that many of them were actually raised in intensity category compared to how strong they might have been in a world without anthropogenic climate change. The costs are already extraordinary, according to Daniel Gilford of Climate Central in Princeton. When it comes to wildlife conservation, one of the underestimated parameters is the “old and wise” individuals in a population. According to a review paper in the journal Science, not only are earth’s old animals in decline, in many species they are vital to recovery and resilience when outside factors endanger numbers. As co-author Lauren Brent of Exeter University points out, these sorts of nuance are not always looked out for in conservation estimates. Chimps have culture, but is their culture cumulative and…